Goal
#6 |
To
provide appropriate training and infrastructure for the conduct of HIV-related
biomedical and behavioral research domestically and internationally. |
Objective
#1 |
Provide
both domestic and international training in biomedical and behavioral
research on HIV.
|
Description
|
Meeting
the needs of research on HIV/AIDS requires recruiting and training basic,
clinical, and behavioral scientists in the United States and abroad in
the many disciplines necessary to carry out this diverse scientific agenda.
|
Action
Steps
|
- Maintain
pre-doctoral and post-doctoral training, as well as advanced research
training, in a range of AIDS-related disciplines.
- Sponsor
an annual AIDS Fellows Meeting to promote collaboration and information
dissemination.
- Support
training of scientists and clinical investigators in basic AIDS research
to better link basic and clinical pathogenesis research.
- Stimulate
pre-doctoral and post-doctoral training in prevention, behavior change,
and adherence and compliance to treatment.
- Promote
training of biomedical and behavioral scientists in the use of high-performance
computing systems for HIV-related research.
- Support
training and research capacity to deal with the epidemic of tuberculosis
(TB), including multiple drug resistance associated with HIV infection.
- Maintain
participation in the Fogarty International Center (FIC)-sponsored international
training and research programs and expand these programs by recruiting
trainees from additional countries in Asia and Latin America, with the
long-term goal of providing AIDS-related training for leading health
scientists from all developing countries.
- Explore
new grant mechanisms to link U.S. AIDS research scientists and institutions
with leading AIDS research scientists and institutions in foreign countries.
- Support
both pre-doctoral and post-doctoral training in structural biology.
Support the NIH AIDS Loan Repayment Program to bring scientists and
physicians to the NIH to expand the cadre of trained intramural researchers.
- Support
both pre- and post-doctoral domestic and international AIDS-related
training in epidemiology, biostatistics, and behavioral methodologies.
- Establish
appropriate career training programs for laboratory investigators, clinical
investigators, and translational scientists (i.e. making the transition
from bench to patient).
- Support
training of investigators in applied immunobiology.
- Support
training of basic investigators, clinical investigators, and translational
investigators for OI research.
- Support
training of basic investigators, clinical investigators, and translational
scientists for research on malignancies in HIV-infected patients.
- Collaborate
with other PHS agencies in the development of training regarding HIV
prevention, treatment, research, and education for health care providers,
AIDS service providers, and health educators.
|
Objective
#2 |
Establish
appropriate infrastructure for the conduct of HIV research domestically
and internationally.
|
Description
|
The conduct
of HIV research in the United States and abroad requires establishment
of infrastructure to carry out this research program, including facilities
and instrumentation, computers, data communications, laboratories, and
animal colonies.
|
Action
Steps
|
- Support
facilities to study animal models of pediatric AIDS.
- Foster
animal models to study HIV-related malignancies.
- Support
the Research Facilities Infrastructure Program (RFI) and General Clinical
Research Centers (GCRC) Program.
- Support
use of the National Research and Education Network (NREN) for national
and international collaboration and data communications.
- Provide
for expansion of breeding facilities to ensure the adequate supply of
species of emerging importance, e.g. M. nemestrina.
- Provide
NCRR animal model support tied to needs of basic research grants.
- Provide
for the long-term support of advanced in-country research and research
infrastructure in those developing countries participating in efficacy
trials of candidate HIV vaccines and other priority intervention research.
- Develop
and support animal models predictive of human behavior, specifically,
models of non-human primate behavior of impaired impulse control and
risk-taking.
- Support
laboratory and biocontainment facilities for primate research.
- Support
the Internet connections program at health sciences centers and hospitals
for research and patient care.
- Establish
and support repositories of samples obtained from individuals with HIV
infection for current and future studies.
- Increase
support for screening the development of HIV macaque monkey models.
Develop and support Regional Primate Research Center (RPRC) expertise
in molecular immunology, peptide biochemistry, and pharmacology.
- Provide
for the establishment of specific pathogen-free (SPF) non-human primate
programs at all the RPRCs.
- Provide
further support for the development of SPF macaque colonies.
|
Resources
|
FY95
|
FY96
|
FY96
|
$
46.5 million
|
$
44.6 million
|
$
44.3 million
|
Populations
Served
|
All populations.
|
Constituency
Involvement
|
Researchers,
clinicians, community and patient representatives, and NIH-affiliated
advisory councils and committees.
|