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IT WAS ADDED 11/21/2014 BY MICHAEL LINGENFELTER AT THE NATIONAL ARCHIVES AND RECORDS ADMINISTRATION --><p align="center"><font face="Georgia, Times New Roman, Times, serif" size="4"><i><font size="2" color="#435250"><a name="top"></a>The
National AIDS Strategy</font></i></font></p>
<p align="center"><font face="Georgia, Times New Roman, Times, serif" size="4"><font size="2" color="#435250"><b><i>Appendix
B: Research<br>
</i></b></font></font> <font face="Georgia, Times New Roman, Times, serif" size="3" color="#435250"><b><i>
Department of Commerce</i></b></font></p>
<p><br>
</p>
<table border="1" cellpadding="5" bordercolor="#8A9F9C" width="95%" bordercolordark="#8A9F9C" bordercolorlight="#D2D2D2" cellspacing="0" align="center">
<tr valign="top">
<td bgcolor="#D2D2D2" width="149"><font size="-1" face="Georgia, Times New Roman, Times, serif"><b>Goal</b></font></td>
<td colspan="3"><font face="Georgia, Times New Roman, Times, serif" size="-1">To
carry out state-of-the-art research on the prevention and treatment of HIV
infection to promote medical readiness in U.S. military forces.</font></td>
</tr>
<tr valign="top">
<td bgcolor="#FFFFFF" width="149" height="93"><font size="-1" face="Georgia, Times New Roman, Times, serif"><b>Objective
</b></font></td>
<td colspan="3" height="93">
<ol>
<li><font face="Georgia, Times New Roman, Times, serif" size="-1">Support
the development of a safe and effective HIV vaccine. </font></li>
<li><font face="Georgia, Times New Roman, Times, serif" size="-1"> Support
the development of new biochemical and genetic strategies to slow HIV
disease progression </font></li>
<li><font face="Georgia, Times New Roman, Times, serif" size="-1">Support
natural history studies for the purpose of evaluating the efficacy of
intervention strategies. </font></li>
</ol>
</td>
</tr>
<tr valign="top">
<td bgcolor="#FFFFFF" width="149">
<div align="right"><font size="-1" face="Georgia, Times New Roman, Times, serif"><i><b>Action
Steps</b></i></font></div>
</td>
<td colspan="3">
<ol>
<li><font face="Georgia, Times New Roman, Times, serif" size="-1">Define
the global molecular epidemiology of HIV to assist with candidate vaccine
selection. </font></li>
<li><font face="Georgia, Times New Roman, Times, serif" size="-1">Explore
novel vaccine technologies. </font></li>
<li><font face="Georgia, Times New Roman, Times, serif" size="-1">Conduct
vaccine trials in endemic areas. </font></li>
<li><font face="Georgia, Times New Roman, Times, serif" size="-1">Assess
the immune response and efficacy of vaccine candidates. </font></li>
<li><font face="Georgia, Times New Roman, Times, serif" size="-1">Evaluate
potential therapies for treatment of HIV infection and potential for
immune reconstitution. </font></li>
<li><font face="Georgia, Times New Roman, Times, serif" size="-1">Evaluate
prevalence of drug resistance, develop rapid genetic assay for resistant
mutants, and methods for genetic targeting of novel therapies in vivo.
</font></li>
<li><font face="Georgia, Times New Roman, Times, serif" size="-1">Participate
in national surveillance of AZT resistance. </font></li>
<li><font face="Georgia, Times New Roman, Times, serif" size="-1">Develop
a comprehensive panel of immunologic, virologic, and functional parameters
for management of HIV infection. </font></li>
<li><font face="Georgia, Times New Roman, Times, serif" size="-1">Support
natural history studies and specimen repositories.</font></li>
</ol>
</td>
</tr>
<tr valign="top">
<td bgcolor="#FFFFFF" width="149">
<div align="right"><font face="Georgia, Times New Roman, Times, serif" size="-1"><b><i>Descriptions</i></b></font></div>
</td>
<td colspan="3">
<p><font face="Georgia, Times New Roman, Times, serif" size="-1">Vaccine,
therapeutic, and epidemiological research, including vaccine design, development
and testing in the U.S. and overseas locations; epidemiologic studies
of vaccine field studies; and conclusion of drug treatment and behavior
studies.</font></p>
</td>
</tr>
<tr valign="top">
<td bgcolor="#FFFFFF" rowspan="2" width="149">
<div align="right"><font size="-1" face="Georgia, Times New Roman, Times, serif"><i><b>Resources</b></i></font>
</div>
</td>
<td>
<div align="center"><font size="-1" face="Georgia, Times New Roman, Times, serif"><b>FY95</b></font></div>
</td>
<td>
<div align="center"><font size="-1" face="Georgia, Times New Roman, Times, serif"><b>FY96</b></font></div>
</td>
<td>
<div align="center"><font size="-1" face="Georgia, Times New Roman, Times, serif"><b>FY96</b></font></div>
</td>
</tr>
<tr valign="top">
<td>
<div align="right"><font face="Georgia, Times New Roman, Times, serif" size="-1">$
38.5 million</font></div>
</td>
<td>
<div align="right"><font face="Georgia, Times New Roman, Times, serif" size="-1">$
27.7 million</font></div>
</td>
<td>
<div align="right"><font face="Georgia, Times New Roman, Times, serif" size="-1">$
24.0 million</font></div>
</td>
</tr>
<tr valign="top">
<td bgcolor="#FFFFFF" width="149">
<div align="right"><font size="-1" face="Georgia, Times New Roman, Times, serif"><i><b>Populations<br>
Served</b></i></font></div>
</td>
<td colspan="3">
<p><font face="Georgia, Times New Roman, Times, serif" size="-1">Active
duty personnel.</font></p>
</td>
</tr>
<tr valign="top">
<td bgcolor="#FFFFFF" width="149">
<div align="right"><font size="-1" face="Georgia, Times New Roman, Times, serif"><i><b>Constituency<br>
Involvement</b></i></font></div>
</td>
<td colspan="3">
<p><font face="Georgia, Times New Roman, Times, serif" size="-1">Clinicians,
researchers, and active duty personnel.</font></p>
</td>
</tr>
</table>
<p></p>
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